Publications

Full List

‣ Targeted long-read sequencing for high-resolution repeat profiling in myotonic dystrophy type 1
Yoojung Han¹, J.-H. Jang^*, and Hyeshik Chang^*
Experimental & Molecular Medicine (2026), 58:1203–1215

‣ VaxLab: integrated platform for rapid multistrategy mRNA vaccine design
Junsoo Kim¹, Yoojung Han¹, Chae Young Kwon, and Hyeshik Chang^*
Experimental & Molecular Medicine (2026), 58:1149–1157

RNA stability enhancers for durable base-modified mRNA therapeutics
S.-J. Jung¹, J. J. Seo¹, S. Lee¹, S.-I. Hyun, J. Lee, Sojeong Lee, Y. Lee, Hyeshik Chang, H. Lee, J.-H. Kim, and V. N. Kim^*
Nature Biotechnology (2025), in press

3AIM-seq: quality assessment of mRNA therapeutics using sequencing for 3′ polyA tails of in vitro transcribed mRNA
J. Seo¹, H.-J. Park¹, A. Oh¹, C. B. Jeong, S. Kim, Sojeong Lee, C. Kim, Hyeshik Chang, J.-H. Nam^*, and D. Park^*
Molecular Therapy (2025), 33(10):4923–4936

Another common genetic ataxia in South Korea: Spinocerebellar ataxia 36
J. H. Ahn, S. Lee, J. Moon, Yoojung Han, Hyeshik Chang, J. Youn, J. W. Cho^*, and J.-H. Jang^*
European Journal of Human Genetics (2025), 34:515–521

‣ SARS-CoV-2 infection engenders heterogeneous ribonucleoprotein interactions to impede translation elongation in the lungs
Junsoo Kim¹, D. Youn¹, S. Choi¹, Y. W. Lee, D. Sumberzul, J. Yoon, Hanju Lee, J. W. Bae, H. Noh, D. On, S.-M. Hong, S.-H. An, H. J. Jang, S. Y. Kim, Y. B. Kim, J.-Y. Hwang, H.-J. Lee, H. B. Kim, J. W. Park, J.-W. Yun, J.-S. Shin, J.-Y. Seo, K. T. Nam, K.-S. Choi, H.-Y. Lee^*, Hyeshik Chang^*, J. K. Seong^*, and J. Cho^*
Experimental & Molecular Medicine (2023), 55:2541–2552

‣ Functional and Molecular Dissection of HCMV Long Non-coding RNAs
S. Lee¹, H. Kim¹, Ari Hong¹, J. Song¹, S. Lee, M. Kim, S. Hwang, D. Jeong, A. Son, Y. Lee, V. N. Kim, J. Kim, Hyeshik Chang^*, and K. Ahn^*
Scientific Reports (2022), 12:19303

‣ Analyzing Viral Epitranscriptomes Using Nanopore Direct RNA Sequencing
Ari Hong¹, D. Kim¹, V. N. Kim^*, and Hyeshik Chang^*
Journal of Microbiology (2022), 60:867–876

Partitioning RNAs by Length Improves Transcriptome Reconstruction from Short-Read RNA-seq Data
F. R. Ringeling¹, S. Chakraborty¹, C. Vissers, D. Reiman, A. M. Patel, K.-H. Lee, Ari Hong, C.-W. Park, T. Reska, J. Gagneur, Hyeshik Chang, M. Spletter, K.-J. Yoon, G. Ming, H. Song, and S. Canzar^*
Nature Biotechnology (2022), 40:741–750

Viral Hijacking of the TENT4–ZCCHC14 Complex Protects Viral RNAs via Mixed Tailing
D. Kim¹, Y.-s. Lee¹, S.-J. Jung¹, J. Yeo¹, J. J. Seo, Y.-Y. Lee, J. Lim, Hyeshik Chang, J. Song, J. Yang, J.-S. Kim, G. Jung, K. Ahn, and V. N. Kim^*
Nature Structural & Molecular Biology (2020), 27:581–588

‣ The Architecture of SARS-CoV-2 Transcriptome
D. Kim¹, J.-Y. Lee, J.-S. Yang, J. W. Kim, V. N. Kim^*, and Hyeshik Chang^*
Cell (2020), 181(4):914–921.e10

Development of a Laboratory-safe and Low-cost Detection Protocol for SARS-CoV-2 of the Coronavirus Disease 2019 (COVID-19)
J. Won, S. Lee, M. Park, T. Y. Kim, M. G. Park, B. Y. Choi, D. Kim, Hyeshik Chang, V. N. Kim, and C. J. Lee^*
Experimental Neurobiology (2020), 29(2):107–119

Bias-Minimized Quantification of MicroRNA Reveals Widespread Alternative Processing and 3′ End Modification
H. Kim¹, J. Kim¹, K. Kim, Hyeshik Chang, K. You, and V. N. Kim^*
Nucleic Acids Research (2019), 47(5):2630–2640

Mixed Tailing by TENT4A and TENT4B Shields mRNA from Rapid Deadenylation
J. Lim¹, D. Kim¹, Y. Lee¹, M. Ha, M. Lee, J. Yeo, Hyeshik Chang, J. Song, K. Ahn, and V. N. Kim^*
Science (2018), 361(6403):701–704

PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay
H. Yi¹, J. Park¹, M. Ha, J. Lim, Hyeshik Chang, and V. N. Kim^*
Molecular Cell (2018), 70(6):1081–1088.e5

‣ Terminal Uridylyltransferases Execute Programmed Clearance of Maternal Transcriptome in Vertebrate Embryos
Hyeshik Chang¹, J. Yeo¹, J.-g. Kim, H. Kim, J. Lim, M. Lee, H. H. Kim, J. Ohk, H.-Y. Jeon, H. Lee, H. Jung, K.-W. Kim, and V. N. Kim^*
Molecular Cell (2018), 70(1):72–82

mTAIL-seq Reveals Dynamic Poly(A) Tail Regulation in Oocyte-to-Embryo Development
J. Lim¹, M. Lee¹, A. Son, Hyeshik Chang, and V. N. Kim^*
Genes & Development (2016), 30:1671–1682

Regulation of Poly(A) Tail and Translation During the Somatic Cell Cycle
J.-E. Park¹, H. Yi¹, Y. Kim¹, Hyeshik Chang, and V. N. Kim^*
Molecular Cell (2016), 62(3):462-471

Next-Generation Libraries for Robust RNA Interference-Based Genome-Wide Screens
M. Kampmann^1*, M. A. Horlbeck, Y. Chena, J. C. Tsai, M. C. Bassik, L. A. Gilbert, J. E. Villalta, S. C. Kwon, Hyeshik Chang, V. N. Kim, and J. S. Weissman^*
Proceedings of the National Academy of Sciences of the U. S. A. (2015), 112(26):E3384-E3391

Temporal Landscape of MicroRNA-Mediated Host-Virus Crosstalk during Productive Human Cytomegalovirus Infection
S. Kim¹, D. Seo¹, D. Kim, Y. Hong, Hyeshik Chang, D. Baek, V. N. Kim, S. Lee, and K. Ahn^*
Cell Host & Microbe (2015), 17(6):838–851

TUT7 Controls the Fate of Precursor MicroRNAs by Using Three Different Uridylation Mechanisms
B. Kim¹, M. Ha¹, L. Loeff¹, Hyeshik Chang, D. K. Simanshu, S. Li, M. Fareh, D. J. Patel, C. Joo^*, and V. N. Kim^*
EMBO Journal (2015), 35(2):115-236

‣ miRseqViewer: Multi-Panel Visualization of Sequence, Structure and Expression for Analysis of MicroRNA Sequencing Data
I. Jang¹, Hyeshik Chang¹, Y. Jun, S. Park, J. O. Yang, B. Lee, W. Kim, V. N. Kim, and S. Lee^*
Bioinformatics (2015), 31(4):596–598

‣ Uridylation by TUT4 and TUT7 Marks mRNA for Degradation
J. Lim¹, M. Ha¹, Hyeshik Chang¹, S. C. Kwon, D. K. Simanshu, D. J. Patel, and V. N. Kim^*
Cell (2014), 159(6):1365–1376

‣ TAIL-seq: Genome-wide Determination of Poly(A) Tail Length and 3′ End Modifications
Hyeshik Chang¹, J. Lim¹, M. Ha, and V. N. Kim^*
Molecular Cell (2014), 53(6):1044–1052

‣ FitSearch: a Robust Way to Interpret a Yeast Fitness Profile in Terms of Drug’s Mode-of-Action
M. Lee¹, S. Han¹, Hyeshik Chang¹, Y.-S. Kwak, D. M. Weller, and D. Kim^*
BMC Genomics (2014), 14(Suppl 1):S6

Construction of the First Compendium of Chemical-Genetic Profiles in the Fission Yeast Schizosaccharomyces pombe and Comparative Compendium Approach
S. Han¹, M. Lee¹, Hyeshik Chang, M. Nam, H.-O. Park, Y.-S. Kwak, H.-J. Ha, D. Kim, S.-O. Hwang, K.-L. Hoe^*, and D.-U. Kim^*
Biochemical and Biophysical Research Communications (2013), 436(4):613–618

miRGator v3.0: a MicroRNA Portal for Deep Sequencing, Expression Profiling and mRNA Targeting
S. Cho¹, I. Jang, Y. Jun, S. Yoon, M. Ko, Y. Kwon, I. Choi, Hyeshik Chang, D. Ryu, B. Lee, V. N. Kim, W. Kim^*, and S. Lee^*
Nucleic Acids Research (2013), 41(D1):D252–D257

‣ LIN28A is a Suppressor of ER-associated Translation in Embryonic Stem Cells
J. Cho¹, H. Chang¹, S. C. Kwon, B. Kim, Y. Kim, J. Choe, M. Ha, Y. K. Kim, and V. N. Kim^*
Cell (2012), 151(4):765–777

Mono-Uridylation of Pre-MicroRNA as a Key Step in the Biogenesis of Group II Let-7 MicroRNAs
I. Heo¹, M. Ha¹, J. Lim, M.-J. Yoon, J.-E. Park, S. C. Kwon, Hyeshik Chang, and V. N. Kim^*
Cell (2012), 151(3):521–532

Dicer recognizes the 5′ end of RNA for efficient and accurate processing
J.-E. Park¹, I. Heo¹, Y. Tian, D. K. Simanshu, Hyeshik Chang, D. Jee, D. J. Patel, and V. N. Kim^*
Nature (2011), 475(7355):201-205