We are reverse-engineers. Our goal is to unravel the intricate mechanisms by which key regulatory components govern the complex gene regulation network. To accomplish this, we employ a combination of high-throughput biochemistry, bioinformatics data analysis, and machine learning to examine molecular mechanisms at a systems level.

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With a primary focus on developing large-scale experimental methods and novel data analytic toolchains, we strive to gain a more profound understanding of the quantitative nature of post-transcriptional gene regulation. By utilizing single-molecule-level measurements of various RNA states—including RNA modifications, chemical adducts, and poly(A) tail lengths—at a transcriptome scale, we can uncover the hidden rules shaped by multiple cis-regulatory factors.

We are currently seeking motivated graduate students and postdocs to join our collaborative research efforts in this exciting field (more info)!

Our lab is affiliated with the School of Biological Sciences at Seoul National University. Currently, our group’s research is supported by funding from the Center for RNA Research in the Institute for Basic Science (IBS) and the National Research Foundation of Korea’s Excellent Young Researcher program.