We are a vibrant research lab affiliated with the Interdisciplinary Program in Bioinformatics and School of Biological Sciences at Seoul National University, Korea. We aim to understand how the gene expression is regulated post-transcriptionally by the interactions between biological molecules in a quantitative manner.
Currently, we are focused on developing high-throughput experimental methods and analytic tools for a deeper understanding of the quantitative nature of post-transcriptional gene regulation. For example, our new tool, poreplex, based on nanopore direct RNA sequencing enables real-time direct measurement of poly(A) tail lengths with the complete information about the alternative splicing and alternative polyadenylation in biologically purturbed conditions (see Research). Our new technologies are expected to reveal the novel molecular phenomena that had been vastly undetectable using the existing techniques.
We are looking for new graduate students and postdocs to enjoy our explorations together (more info)!
A booklet introducing our lab is also available in Korean.
We uploaded a preprint reporting a cluster of RNA modifications in the SARS-CoV-2 RNAs.Mar 1, 2020
Jun has joined the lab to find interesting things together.Mar 1, 2020
Ari has started grad schoool as the first student in the lab.Sep 8, 2019
We updated Poreplex to 0.5 with the new Guppy compatibility.Mar 13, 2019
Eun-jin joined the lab.Mar 1, 2019
We're officially opening the lab. Yay! 🙌Feb 27, 2019
Poreplex 0.4.1 has been released with ONT Guppy and multi-read fast5 support!Dec 27, 2018
We released a new software, seamlessf5, that helps transitions to the new data format for nanopore sequencing.