We are a vibrant research lab affiliated with the Interdisciplinary Program in Bioinformatics and School of Biological Sciences at Seoul National University, Korea. We aim to understand how the gene expression is regulated post-transcriptionally by the interactions between biological molecules in a quantitative manner.
Currently, we are focused on developing high-throughput experimental methods and analytic tools for a deeper understanding of the quantitative nature of post-transcriptional gene regulation. For example, our new tool, poreplex, based on nanopore direct RNA sequencing enables real-time direct measurement of poly(A) tail lengths with the complete information about the alternative splicing and alternative polyadenylation in biologically perturbed conditions (see Research). Our new technologies are expected to reveal the novel molecular phenomena that had been vastly undetectable using the existing techniques.
We are looking for new postdocs to enjoy our explorations together (more info)!
A booklet introducing our lab is also available in Korean.
Hyeshiks explains why computer scientists should be interested in biology in the Samsung Software Developer Conference 2021.Apr 1, 2021
A genomics expert, Junsoo, joins to strengthen the group's agility.Mar 1, 2021
The lab is getting bigger! Keewon and Hanju join.Feb 17, 2021
Hyeshik tells the human genome sequencing story to middle and high school students on the SNU/KAOS Science Open Lecture.Sep 23, 2020
The lab introduction is published as a part of the POKAS-on webzine.Sep 1, 2020
Yoojung is joining the ranks of the lab members.Aug 25, 2020
Hyeshik uploaded a YouTube video about the molecular biology of SARS-CoV-2.Mar 15, 2020
We uploaded a preprint reporting a cluster of RNA modifications in the SARS-CoV-2 RNAs.Mar 1, 2020
Ari has started grad schoool as the first student in the lab.